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A macrophage migration-inhibition test was negative in the presence of both quinidine and allopurinol. Up to 300 milligrams (mg) of allopurinol can be taken at one time. The mechanism is unknown and pharmacokinetic studies with hydrochlorothiazide have not demonstrated any effects on the disposition of allopurinol or oxipurinol (its major metabolite). However, allopurinol did not cause birth defects or other problems in rats or rabbits given doses up to 20 times the amount usually given to humans. Allopurinol will not relieve a gout attack that has already started.

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