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In clinical trials, Fosamax 40 mg once daily for six months produced significant decreases in serum alkaline phosphatase as well as in urinary markers of bone collagen degradation. Fosamax) causes a shift of bone balance toward bone formation by inhibiting bone resorption and has been shown to increase bone mass. Similar decreases were seen in patients in osteoporosis prevention studies who received Fosamax 5 mg/day. Take the Fosamax tablet first thing in the morning, at least 30 minutes before you eat or drink anything or take any other medicine. For at least the first 30 minutes after taking a Fosamax tablet, do not lie down or recline; do not eat or drink anything other than plain water; and do not take any other medicines including vitamins, calcium, or antacids. Similar reductions in the rate of bone turnover were observed in postmenopausal women during one-year studies with once weekly Fosamax 70 mg for the treatment of osteoporosis and once weekly Fosamax 35 mg for the prevention of osteoporosis.

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