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The mechanism is unknown and pharmacokinetic studies with hydrochlorothiazide have not demonstrated any effects on the disposition of allopurinol or oxipurinol (its major metabolite). Adverse effects can be minimized by increased hydration, urine alkalinization, and the prophylactic administration of a xanthine oxidase inhibitor such as ZYLOPRIM® (allopurinol). However, allopurinol did not cause birth defects or other problems in rats or rabbits given doses up to 20 times the amount usually given to humans. You will need to discuss the benefits and risks of using Allopurinol while you are pregnant. After you have been taking allopurinol regularly for several months, the attacks may stop completely. Keep Allopurinol out of the reach of children and away from pets.

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