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Co-administration of both gemfibrozil and itraconazole with Prandin resulted in a 19-fold higher repaglinide AUC and prolonged repaglinide half-life to 6. Of Prandin-treated patients with symptomatic hypoglycemia, none developed coma or required hospitalization. Combination therapy with Prandin and metformin resulted in significantly greater improvement in glycemic control as compared to repaglinide or metformin monotherapy. 25 mg Prandin (after 4 days of twice daily clarithromycin 250 mg) resulted in a 40% and 67% increase in repaglinide AUC and Cmax, respectively. HbA1c for the Prandin- treated groups (1 and 4 mg groups combined) at the end of the study was decreased compared to the placebo-treated group in previously naпve patients and in patients previously treated with oral hypoglycemic agents by 2. There was no average gain in body weight when patients previously treated with oral hypoglycemic agents were switched to Prandin.

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